1-linoleoyl-gpi (18:2)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.481
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
21.656
Reference Allele:
A
-log10(P):
-237.801
MAF:
0.344
Beta (Num):
0.164
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.316
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerolipid metabolism, Phospholipid biosynthesis.6[1]

Ratio Explanation:

The ratio reflects FADS1 activity; higher values suggest decreased conversion of linoleic acid precursors to arachidonic acid-containing products, indicating reduced enzyme function.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity alters fatty acid composition, increasing the ratio.7[1], 8[2] This dysregulation of lipid metabolism is linked to inflammatory conditions and disorders of lipoprotein metabolism.2[3], 9[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data