1-linoleoyl-gpi (18:2)* to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.320
Position:
61569830
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
12.835
Reference Allele:
C
-log10(P):
-85.151
MAF:
0.340
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.155
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Long Chain Polyunsaturated Fatty Acid (n3 and n6) biosynthesis.5[1]

Ratio Explanation:

This ratio may reflect the balance between phospholipid degradation and the synthesis of long-chain omega-3 fatty acids, influenced by FADS enzyme activity.1[1], 2[2], 6[3], 7[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants influence the levels of long-chain polyunsaturated fatty acids.3[1], 8[2] Altered fatty acid profiles are associated with an increased risk for inflammatory conditions, cardiovascular disease, and certain cancers, which are listed as associated phenotypes.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data