1-linoleoyl-gpi (18:2)* to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.241
Position:
61557803
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
11.852
Reference Allele:
T
-log10(P):
-72.943
MAF:
0.347
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.079
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis, Fatty acid metabolism.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Sphingolipid metabolism.8[1], 9[2]

Ratio Explanation:

This ratio may reflect FADS enzyme activity on the linoleic acid (18:2) component of 1-linoleoyl-gpi, relative to sphingomyelin pathway activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, affecting the balance of lipids that mediate inflammation.1[1], 10[2], 11[3] This can contribute to phenotypes like hypercholesterolemia, asthma, and inflammatory bowel disease by modifying inflammatory and metabolic pathways.10[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data