1-linoleoyl-gpi (18:2)* to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.357
Position:
61549025
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
13.939
Reference Allele:
G
-log10(P):
-100.016
MAF:
0.339
Beta (Num):
0.163
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.194
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Long-chain fatty acid metabolism.8[1], 9[2]

Ratio Explanation:

The ratio reflects the balance between a lysophospholipid and a long-chain polyunsaturated fatty acid, potentially indicating altered fatty acid desaturation and incorporation into phospholipids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 and FADS2 affect the efficiency of polyunsaturated fatty acid synthesis.1[1], 2[2], 3[3], 5[4] This altered lipid metabolism is linked to a higher risk for inflammatory conditions like asthma and various metabolic and cardiovascular diseases, including hypercholesterolemia and cholelithiasis.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data