1-linoleoyl-gpi (18:2)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.432
Position:
61570783
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
18.864
Reference Allele:
T
-log10(P):
-181.098
MAF:
0.340
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.267
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism, Glycerophospholipid metabolism.6[1], 7[2], 8[3], 9[4], 10[5]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.11[1], 12[2], 13[3], 14[4], 15[5]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid components and fatty acid derivatives, potentially indicating activity of fatty acid desaturase enzymes like FADS1/FADS2.1[1], 2[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variations in FADS1/FADS2 influence the efficiency of polyunsaturated fatty acid synthesis, affecting the availability of arachidonic acid, a precursor for inflammatory mediators, thereby potentially modulating risk for inflammatory conditions like asthma and dermatitis, and influencing lipid profiles linked to heart disease and cholelithiasis.1[1], 2[2], 16[3], 5[4], 17[5], 18[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data