1-oleoyl-gpi (18:1) to glycerophosphorylcholine (gpc)

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of glycerophosphorylcholine (gpc)
Metabolite Accession: GCST90199629
Name: glycerophosphorylcholine (gpc)
Hmdb Id: HMDB0000086
Super Pathway: NA
Sub Pathway: NA
Inchikey: SUHOQUVVVLNYQR

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.157
Position:
61581764
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
8.468
Reference Allele:
T
-log10(P):
-38.229
MAF:
0.308
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.066
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Lysolipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Choline metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect FADS activity; lower FADS function can alter fatty acid pools, impacting 1-oleoyl-GPI levels relative to GPC, a phospholipid breakdown product.4[1], 10[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter polyunsaturated fatty acid metabolism, which is linked to lipoprotein metabolism, cholelithiasis, and inflammation, explaining associations with hypercholesterolemia and asthma.3[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data