1-oleoyl-gpi (18:1) to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.267
Position:
54677189
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
12.654
Reference Allele:
C
-log10(P):
-82.833
MAF:
0.435
Beta (Num):
0.093
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis, Phosphatidylinositol metabolism

Denominator Metabolite Explanation:

GPI anchor biosynthesis, Phosphatidylinositol acyl-chain remodeling6[1], 9[2], 10[3]

Ratio Explanation:

This ratio of a lysophosphatidylinositol to a mature phosphatidylinositol reflects the activity of MBOAT7, which acylates lysophospholipids, a key step in phospholipid remodeling.6[1], 11[2], 7[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 activity, indicated by an elevated metabolite ratio, is associated with altered lipid metabolism and inflammation, which links to lipoprotein disorders, asthma, and dermatitis.12[1], 13[2], 14[3], 15[4], 16[5], 1[6]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data