1-oleoyl-gpi (18:1) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.180
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
8.535
Reference Allele:
C
-log10(P):
-38.808
MAF:
0.339
Beta (Num):
0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.085
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.4[1], 5[2], 6[3], 7[4], 8[5]

Denominator Metabolite Explanation:

Alpha-linolenic acid metabolism, Fatty acid biosynthesis.3[1], 9[2], 10[3]

Ratio Explanation:

The ratio of 1-oleoyl-GPI to DHA reflects the relative activity of fatty acid desaturation pathways, influenced by FADS1/FADS2, impacting the balance of these lipids.11[1], 12[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 gene activity alter the balance of fatty acid metabolites, like the 1-oleoyl-gpi to DHA ratio, which is linked to dyslipidemia and inflammatory conditions like hypercholesterolaemia, cholelithiasis, and asthma.13[1], 14[2], 15[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data