1-oleoyl-gpi (18:1) to 1,2-dipalmitoyl-gpc (16:0/16:0)

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1,2-dipalmitoyl-gpc (16:0/16:0)
Metabolite Accession: GCST90199660
Name: 1,2-dipalmitoyl-gpc (16:0/16:0)
Hmdb Id: HMDB0000564
Super Pathway: NA
Sub Pathway: NA
Inchikey: KILNVBDSWZSGLL

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.313
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
15.039
Reference Allele:
T
-log10(P):
-116.024
MAF:
0.346
Beta (Num):
0.092
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.221
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis, Lysophospholipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects FADS1 activity; higher levels indicate a shift in the cellular fatty acid pool, impacting the composition of both GPI-anchored proteins and membrane phospholipids.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid metabolism, which is reflected in the lipid ratio and linked to inflammation and altered lipid metabolism, driving phenotypes like cholelithiasis, inflammatory bowel disease, and dyslipidemia.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data