1-oleoyl-gpi (18:1) to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.237
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
10.840
Reference Allele:
C
-log10(P):
-61.373
MAF:
0.339
Beta (Num):
0.095
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.142
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2], 8[3], 9[4]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

This ratio reflects the balance between glycerophospholipid and polyunsaturated fatty acid metabolism, which is influenced by the activity of FADS enzymes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter their desaturase activity, impacting the balance of fatty acids.2[1], 3[2] This dysregulation of lipid metabolism is linked to phenotypes like cholelithiasis, hypercholesterolemia, and other disorders of lipoprotein metabolism.14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data