1-oleoyl-gpi (18:1) to stearidonate (18:4n3)

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs97384

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.213
Position:
61624181
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
9.804
Reference Allele:
C
-log10(P):
-50.576
MAF:
0.376
Beta (Num):
0.095
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.118
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS3 FADS1 RAB3IL1 FEN1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the activity of FADS enzymes, balancing omega-9 (oleic acid) and omega-3 (stearidonate) fatty acid pathways which compete for these enzymes.7[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 alter desaturase efficiency, impacting the balance of various polyunsaturated fatty acids.11[1], 12[2] This dysregulation affects systemic lipid levels, contributing to phenotypes like hypercholesterolemia, lipoprotein disorders, and related cardiovascular risks.2[3], 13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data