1-oleoyl-gpi (18:1) to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.207
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
10.056
Reference Allele:
T
-log10(P):
-53.101
MAF:
0.308
Beta (Num):
0.092
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of 1-oleoyl-gpi (18:1) to 1-stearoyl-gpc (18:0) reflects desaturase activity, converting saturated to monounsaturated fatty acids, a process influenced by FADS1.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters fatty acid desaturation activity, affecting the 18:1/18:0 balance.9[1], 10[2] This dysregulation impacts lipid profiles and inflammatory responses, linking to phenotypes such as lipoprotein disorders, asthma, and dermatitis.11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data