1-oleoyl-gpi (18:1) to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.184
Position:
61581764
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
9.029
Reference Allele:
T
-log10(P):
-43.197
MAF:
0.308
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, GPI-anchor biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of 1-oleoyl-GPI to 1-stearoyl-GPE may reflect FADS1 activity, which influences the balance of unsaturated to saturated fatty acids in phospholipids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters fatty acid metabolism, influencing the ratio of oleoyl- to stearoyl-containing phospholipids.10[1], 11[2], 12[3] This dysregulation is associated with altered inflammatory responses and lipid profiles, contributing to phenotypes like hypercholesterolemia, asthma, and inflammatory skin conditions.13[4], 14[5], 15[6], 16[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data