1-oleoyl-gpi (18:1) to 1-(1-enyl-palmitoyl)-gpc (p-16:0)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.259
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
12.293
Reference Allele:
T
-log10(P):
-78.305
MAF:
0.346
Beta (Num):
0.092
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.167
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Lysophospholipid metabolism, GPI-anchor biosynthesis.3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis, Phosphatidylcholine biosynthesis.7[1], 8[2]

Ratio Explanation:

The ratio reflects fatty acid desaturation activity, where FADS1/FADS2 influence the balance between different polyunsaturated fatty acids affecting membrane composition and signaling.9[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, influenced by genetic factors, impacts the balance of polyunsaturated fatty acids. This dysregulation of lipid metabolism is associated with an increased risk for inflammatory conditions and metabolic disorders like cholelithiasis and dyslipidemia.9[1], 11[2], 12[3], 10[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data