1-oleoyl-gpi (18:1) to 1-(1-enyl-stearoyl)-gpe (p-18:0)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Metabolite Accession: GCST90199910
Name: 1-(1-enyl-stearoyl)-gpe (p-18:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.217
Position:
61581764
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
10.254
Reference Allele:
T
-log10(P):
-55.139
MAF:
0.308
Beta (Num):
0.092
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.125
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.4[1]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis.5[1]

Ratio Explanation:

The ratio reflects FADS1 activity; higher FADS1 desaturase activity alters the balance of fatty acid precursors available for incorporation into complex lipids like GPIs and plasmalogens.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered FADS1 activity, reflected in the ratio, impacts the balance of pro-inflammatory and anti-inflammatory polyunsaturated fatty acids. This dysregulation of lipid metabolism and inflammation likely contributes to the associated phenotypes, including hypercholesterolemia, phlebitis, and asthma.3[1], 6[2]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data