1-oleoyl-gpi (18:1) to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)*
Metabolite Accession: GCST90200010
Name: sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)*
Hmdb Id: HMDB0012104
Super Pathway: NA
Sub Pathway: NA
Inchikey: VBFKEZGCUWHGSK

Associated Genomic Regions

Region: rs174599

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.197
Position:
61621556
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
9.422
Reference Allele:
G
-log10(P):
-46.867
MAF:
0.375
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.099
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS3 FADS1 RAB3IL1 FEN1

LLM Analysis

Numerator Metabolite Explanation:

GPI-anchor biosynthesis8[1], 9[2], 10[3], 11[4]

Denominator Metabolite Explanation:

Sphingolipid metabolism12[1], 13[2], 14[3], 15[4]

Ratio Explanation:

This ratio may reflect the balance between GPI anchor and sphingolipid synthesis, influenced by FADS-mediated desaturation of fatty acids that serve as precursors for various complex lipids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter polyunsaturated fatty acid metabolism, impacting the ratio. This dysregulation of lipid and inflammatory precursors plausibly links to phenotypes such as asthma, dermatitis, hypercholesterolemia, and phlebitis by altering cell membrane composition and signaling.1[1], 2[2], 16[3], 17[4], 18[5], 19[6], 20[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data