1-oleoyl-gpi (18:1) to 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Metabolite Accession: GCST90200062
Name: 1-palmitoyl-2-arachidonoyl-gpi (16:0/20:4)*
Hmdb Id: HMDB0009789
Super Pathway: NA
Sub Pathway: NA
Inchikey: KIQYUSYSJTUGFZ

Associated Genomic Regions

Region: rs174549

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.255
Position:
61571382
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
12.583
Reference Allele:
G
-log10(P):
-81.934
MAF:
0.304
Beta (Num):
0.094
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.161
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.165
Position:
54677189
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
8.573
Reference Allele:
C
-log10(P):
-39.138
MAF:
0.435
Beta (Num):
0.093
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophosphoinositol metabolism, Land's cycle.7[1], 5[2], 8[3]

Ratio Explanation:

The ratio of 1-oleoyl-gpi to 1-palmitoyl-2-arachidonoyl-gpi represents the balance between lysophosphatidylinositol and reacylated phosphatidylinositol, reflecting MBOAT7 enzyme activity.1[1], 9[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 function alters phosphatidylinositol remodeling, leading to an accumulation of lysophosphatidylinositols.9[1], 3[2], 10[3] This dysregulation is associated with liver disease and phenotypes such as cholelithiasis and disorders of lipoprotein metabolism.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data