1-oleoyl-gpi (18:1) to 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Metabolite Accession: GCST90200070
Name: 1-(1-enyl-palmitoyl)-2-palmitoleoyl-gpc (p-16:0/16:1)*
Hmdb Id: HMDB0011207
Super Pathway: NA
Sub Pathway: NA
Inchikey: FZMYLOBGNYZPQO

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.203
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
9.697
Reference Allele:
T
-log10(P):
-49.521
MAF:
0.346
Beta (Num):
0.092
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Inositol phosphate metabolism.3[1]

Denominator Metabolite Explanation:

Ether lipid metabolism, Glycerophospholipid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio reflects the relative abundance of a lysophosphatidylinositol and a plasmalogen, whose fatty acid compositions (e.g., 18:1, 16:1) are influenced by FADS activity.6[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid synthesis, impacting lipid profiles and inflammation.7[1], 8[2] This plausibly links the variants to phenotypes like hypercholesterolemia, cholelithiasis (gallstones), inflammatory bowel disease, and asthma through dysregulated lipid and inflammatory mediator production.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data