1-oleoyl-gpi (18:1) to 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.261
Position:
61557803
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
12.224
Reference Allele:
T
-log10(P):
-77.455
MAF:
0.346
Beta (Num):
0.092
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.168
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis6[1], 7[2], 8[3]

Ratio Explanation:

FADS activity alters the fatty acid pool available for incorporation into complex lipids, likely affecting the balance between oleoyl-containing GPIs and palmitoyl-containing plasmalogens.9[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters LC-PUFA synthesis, impacting the composition of complex lipids.10[1], 9[2] This dysregulation is associated with hypercholesterolemia, cholelithiasis, and type 2 diabetes, likely through effects on lipid metabolism and inflammation.11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data