1-oleoyl-gpi (18:1) to cerotoylcarnitine (c26)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of cerotoylcarnitine (c26)*
Metabolite Accession: GCST90200136
Name: cerotoylcarnitine (c26)*
Hmdb Id: HMDB0006347
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOCKWDDTAHPJSX

Associated Genomic Regions

Region: rs174549

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.179
Position:
61571382
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
8.274
Reference Allele:
G
-log10(P):
-36.582
MAF:
0.304
Beta (Num):
0.094
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.085
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, Lysolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle.6[1], 7[2]

Ratio Explanation:

The ratio of 1-oleoyl-gpi (18:1) to cerotoylcarnitine (c26) may reflect the balance between glycerophospholipid synthesis and very long-chain fatty acid beta-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid metabolism, influencing lipid profiles and inflammatory responses.1[1], 8[2], 9[3] This is linked to phenotypes like altered cholesterol levels, and inflammatory conditions such as dermatitis and sinusitis, which are observed in the associated FinnGen and BioBank Japan traits.1[4], 2[5], 8[6], 10[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data