1-oleoyl-gpi (18:1) to docosatrienoate (22:3n6)*

Numerator Metabolite

Structure of 1-oleoyl-gpi (18:1)
Metabolite Accession: GCST90199822
Name: 1-oleoyl-gpi (18:1)
Hmdb Id: HMDB0061693
Super Pathway: NA
Sub Pathway: NA
Inchikey: UGDOFRYHDCDVHD

Denominator Metabolite

Structure of docosatrienoate (22:3n6)*
Metabolite Accession: GCST90200138
Name: docosatrienoate (22:3n6)*
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.287
Position:
61579463
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
10.863
Reference Allele:
A
-log10(P):
-61.621
MAF:
0.338
Beta (Num):
0.094
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.193
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism2[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1]

Ratio Explanation:

This ratio may reflect FADS1/FADS2 activity, balancing glycerophospholipid synthesis containing oleic acid with the production of long-chain n-6 polyunsaturated fatty acids.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in FADS1/FADS2 alter polyunsaturated fatty acid levels, impacting inflammatory and metabolic processes, which contributes to the risk of associated phenotypes like inflammatory bowel disease, type 2 diabetes, and valvular heart disease.4[1], 5[2], 6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data