thymol sulfate to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of thymol sulfate
Metabolite Accession: GCST90199827
Name: thymol sulfate
Hmdb Id: HMDB0062720
Super Pathway: NA
Sub Pathway: NA
Inchikey: NODSEPOUFZPJEQ

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs12212049

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.200
Position:
25759066
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-9.410
Reference Allele:
G
-log10(P):
-46.750
MAF:
0.412
Beta (Num):
-0.110
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.090
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A4 SLC17A1 HIST1H2BA HIST1H2AA SCGN

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Sulfation5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Steroidogenesis, Sulfation8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect the transport activity of SLC17A4, which potentially transports both sulfated xenobiotic (thymol sulfate) and steroid (androstenediol disulfate) compounds.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SLC17A4 variants impact its function as a urate transporter, directly influencing serum uric acid and creatinine levels.11[1], 12[2], 13[3], 14[4] Its role in transporting other anions and influencing systemic metabolic processes could explain the association with various hematological phenotypes.15[5], 16[6], 17[7]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data