thymol sulfate to carboxyethyl-gaba

Numerator Metabolite

Structure of thymol sulfate
Metabolite Accession: GCST90199827
Name: thymol sulfate
Hmdb Id: HMDB0062720
Super Pathway: NA
Sub Pathway: NA
Inchikey: NODSEPOUFZPJEQ

Denominator Metabolite

Structure of carboxyethyl-gaba
Metabolite Accession: GCST90199918
Name: carboxyethyl-gaba
Hmdb Id: HMDB0002201
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRGQUICKDUQCKO

Associated Genomic Regions

Region: rs1185567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.241
Position:
25818588
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-11.004
Reference Allele:
G
-log10(P):
-63.180
MAF:
0.443
Beta (Num):
-0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.137
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, sulfation of thymol.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

GABA metabolism, polyamine catabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio likely reflects altered renal or intestinal clearance by SLC17A4, which transports urate and other organic anions, potentially including thymol sulfate.2[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC17A4 function likely impairs renal and intestinal urate excretion, leading to higher serum uric acid and creatinine, which are key phenotypes.1[1], 10[2], 11[3] The transporter's impact on red blood cell indices is less clear but may be secondary.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data