thymol sulfate to 2-aminooctanoate

Numerator Metabolite

Structure of thymol sulfate
Metabolite Accession: GCST90199827
Name: thymol sulfate
Hmdb Id: HMDB0062720
Super Pathway: NA
Sub Pathway: NA
Inchikey: NODSEPOUFZPJEQ

Denominator Metabolite

Structure of 2-aminooctanoate
Metabolite Accession: GCST90199937
Name: 2-aminooctanoate
Hmdb Id: HMDB0000991
Super Pathway: NA
Sub Pathway: NA
Inchikey: AKVBCGQVQXPRLD

Associated Genomic Regions

Region: rs1183200

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.214
Position:
25818646
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-9.819
Reference Allele:
C
-log10(P):
-50.725
MAF:
0.443
Beta (Num):
-0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Sulfation pathway.5[1], 6[2]

Denominator Metabolite Explanation:

Amino acid metabolism, Fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

This ratio may reflect SLC17A4 transport activity; altered function could impact the excretion or transport of thymol sulfate and 2-aminooctanoate, affecting their relative concentrations.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC17A4 function, indicated by the altered ratio, could impair intestinal urate excretion, leading to higher serum uric acid and creatinine, and potentially affecting hematological parameters through kidney function and systemic inflammation.2[1], 3[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data