thymol sulfate to phenylacetylglutamate

Numerator Metabolite

Structure of thymol sulfate
Metabolite Accession: GCST90199827
Name: thymol sulfate
Hmdb Id: HMDB0062720
Super Pathway: NA
Sub Pathway: NA
Inchikey: NODSEPOUFZPJEQ

Denominator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Associated Genomic Regions

Region: rs3757131

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.271
Position:
25783909
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
-11.322
Reference Allele:
C
-log10(P):
-66.749
MAF:
0.427
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.166
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Sulfation5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Phenylalanine Metabolism8[1], 9[2], 10[3]

Ratio Explanation:

The ratio of thymol sulfate to phenylacetylglutamate could reflect the relative activity of intestinal detoxification and amino acid metabolism, potentially influenced by the transporter SLC17A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role in transporting urate and thyroid hormones provides a direct link to the observed phenotypes of altered uric acid levels and red blood cell parameters (MCHC, MCH, Hb, MCV), as thyroid hormones are crucial for erythropoiesis.11[1], 2[2], 12[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data