thymol sulfate to hydroxy-cmpf*

Numerator Metabolite

Structure of thymol sulfate
Metabolite Accession: GCST90199827
Name: thymol sulfate
Hmdb Id: HMDB0062720
Super Pathway: NA
Sub Pathway: NA
Inchikey: NODSEPOUFZPJEQ

Denominator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1185567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.213
Position:
25818588
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
-10.066
Reference Allele:
G
-log10(P):
-53.203
MAF:
0.443
Beta (Num):
-0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.109
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Furanoid fatty acid metabolism5[1], 6[2]

Ratio Explanation:

The ratio may reflect the transport activity of SLC17A4, which influences the levels of various organic anions, including urate and potentially other metabolites.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A missense variant in SLC17A4, an intestinal anion exporter of urate and thyroid hormones, is associated with altered serum creatinine and uric acid.1[1], 2[2] This suggests the variant impacts SLC17A4's transport function, affecting renal and metabolic phenotypes.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data