3-methyladipate to n2,n5-diacetylornithine

Numerator Metabolite

Structure of 3-methyladipate
Metabolite Accession: GCST90199829
Name: 3-methyladipate
Hmdb Id: HMDB0000555
Super Pathway: NA
Sub Pathway: NA
Inchikey: SYEOWUNSTUDKGM

Denominator Metabolite

Structure of n2,n5-diacetylornithine
Metabolite Accession: GCST90199954
Name: n2,n5-diacetylornithine
Hmdb Id: HMDB0240345
Super Pathway: NA
Sub Pathway: NA
Inchikey: XUYANFPPYJSBPU

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.161
Position:
25794431
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
8.028
Reference Allele:
G
-log10(P):
-34.547
MAF:
0.454
Beta (Num):
0.082
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.079
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Phytanic acid catabolism, ω-oxidation. 5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Urea cycle, N-acetyl-L-amino acid metabolism. 8[1], 9[2]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, potentially influencing both organic anion and amino acid derivative levels, but a direct link is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role in urate transport is the most direct link to phenotypes like uric acid levels and related conditions such as gout. 10[1], 11[2]Its influence on red blood cell traits may be secondary to its transport functions or other unknown mechanisms.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data