3-methyladipate to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Structure of 3-methyladipate
Metabolite Accession: GCST90199829
Name: 3-methyladipate
Hmdb Id: HMDB0000555
Super Pathway: NA
Sub Pathway: NA
Inchikey: SYEOWUNSTUDKGM

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs2279502

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.169
Position:
151917652
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-8.872
Reference Allele:
A
-log10(P):
-41.780
MAF:
0.398
Beta (Num):
-0.069
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.100
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, dicarboxylate metabolism.4[1], 5[2], 6[3], 7[4], 8[5]

Denominator Metabolite Explanation:

Fatty acid metabolism, dicarboxylate metabolism.9[1], 10[2], 4[3]

Ratio Explanation:

An elevated ratio of 3-methyladipate to its carnitine conjugate suggests a block or altered flux in dicarboxylic acid metabolism, potentially influenced by THEM4's thioesterase activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype link was provided in the input data, so a causal relationship cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data