3-methyladipate to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of 3-methyladipate
Metabolite Accession: GCST90199829
Name: 3-methyladipate
Hmdb Id: HMDB0000555
Super Pathway: NA
Sub Pathway: NA
Inchikey: SYEOWUNSTUDKGM

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2762353

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.154
Position:
25794431
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
7.652
Reference Allele:
G
-log10(P):
-31.554
MAF:
0.454
Beta (Num):
0.082
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.072
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, ω-oxidation. 7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Xenobiotic metabolism, amino acid metabolism.

Ratio Explanation:

The ratio reflects altered transport of organic anions by SLC17A4, potentially impacting the excretion or retention of 3-methyladipate relative to a glutamine conjugate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The missense variant in SLC17A4, a known urate transporter, likely alters its function. 1[1], 2[2], 3[3], 4[4], 5[5], 6[6]This could lead to changes in the transport of various organic anions, influencing serum levels of uric acid, creatinine, and affecting hematological parameters, all of which are observed phenotypes.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data