1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.196
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
9.400
Reference Allele:
A
-log10(P):
-46.654
MAF:
0.344
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.097
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid Metabolism, Fatty Acid Metabolism4[1]

Denominator Metabolite Explanation:

Glycerophospholipid Metabolism, Lysolipid Metabolism5[1], 6[2]

Ratio Explanation:

The ratio of PE(18:0/18:1) to LysoPC(18:0) reflects desaturation activity, governed by FADS enzymes, converting stearic acid (18:0) to oleic acid (18:1).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting fatty acid and cholesterol metabolism.7[1], 8[2] This dysregulation is linked to hypercholesterolemia, cholelithiasis, and inflammatory conditions, likely driven by changes in lipid mediator production and cholesterol transport.9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data