1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.172
Position:
61557803
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
10.100
Reference Allele:
T
-log10(P):
-53.550
MAF:
0.346
Beta (Num):
0.095
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.078
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio may reflect the activity of an acyltransferase that incorporates oleic acid (18:1) onto a lysophospholipid, potentially influenced by FADS-mediated fatty acid metabolism.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 influences fatty acid metabolism, altering the balance of fatty acids incorporated into phospholipids.1[1], 3[2] This dysregulation of lipid profiles is a known risk factor for the observed phenotypes, including cholelithiasis, dyslipidemia, and inflammatory conditions like asthma and inflammatory bowel disease.4[3], 5[4], 6[5], 7[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data