1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Metabolite Accession: GCST90200065
Name: 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Hmdb Id: HMDB0009012
Super Pathway: NA
Sub Pathway: NA
Inchikey: XYYHNDVKALDFHQ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.170
Position:
61569830
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
10.389
Reference Allele:
C
-log10(P):
-56.545
MAF:
0.339
Beta (Num):
0.098
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.072
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the activity of FADS enzymes; lower FADS2 activity results in less synthesis of long-chain fatty acids like DHA (22:6) from precursors.10[1], 11[2], 12[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, indicated by the ratio, alters polyunsaturated fatty acid profiles, which is linked to dyslipidemia and an increased risk for type 2 diabetes.1[1], 13[2], 14[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data