1-stearoyl-2-oleoyl-gpe (18:0/18:1) to 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.441
Position:
61579463
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
23.192
Reference Allele:
A
-log10(P):
-272.306
MAF:
0.337
Beta (Num):
0.099
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.342
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio reflects FADS1/FADS2 activity, comparing a phosphatidylethanolamine with oleic acid against a phosphatidylcholine with arachidonic acid, a direct product of FADS-mediated synthesis.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants alter the synthesis of proinflammatory arachidonic acid (20:4), influencing the balance of lipid mediators.4[1], 5[2], 6[3] This dysregulation is linked to inflammatory and metabolic conditions, including benign colon neoplasms, a finding supported by Mendelian randomization.7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data