1-stearoyl-2-oleoyl-gpe (18:0/18:1) to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Metabolite Accession: GCST90199831
Name: 1-stearoyl-2-oleoyl-gpe (18:0/18:1)
Hmdb Id: HMDB0008993
Super Pathway: NA
Sub Pathway: NA
Inchikey: JQKOHRZNEOQNJE

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.255
Position:
61579463
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
9.245
Reference Allele:
A
-log10(P):
-45.195
MAF:
0.337
Beta (Num):
0.099
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.156
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis

Ratio Explanation:

The ratio of a common phospholipid to a very-long-chain omega-3 fatty acid reflects FADS enzyme activity, crucial for synthesizing anti-inflammatory versus pro-inflammatory lipid mediators.3[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetically determined FADS1/FADS2 activity alters the balance of pro-inflammatory and anti-inflammatory PUFAs, impacting lipid profiles and inflammatory responses, which contributes to the risk of dyslipidemia, T2D, and inflammatory conditions like IBD and asthma.5[1], 3[2], 6[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data