hexanoylglutamine to 3-hydroxydecanoate

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Associated Genomic Regions

Region: rs6684114

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.237
Position:
151928715
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
15.238
Reference Allele:
A
-log10(P):
-119.050
MAF:
0.316
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.205
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.328
Position:
25794431
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-22.682
Reference Allele:
G
-log10(P):
-260.585
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.011
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, amino acid conjugation.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.9[1], 10[2]

Ratio Explanation:

The ratio reflects altered medium-chain fatty acid metabolism due to ACADM dysfunction, causing accumulation of hexanoyl-CoA (forming hexanoylglutamine) and 3-hydroxydecanoate from their respective precursors.5[1], 11[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Impaired ACADM function disrupts fatty acid oxidation, a primary energy source, which can affect the development and function of hematopoietic cells, leading to altered red blood cell indices.5[1], 11[2]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data