hexanoylglutamine to 3-hydroxylaurate

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Associated Genomic Regions

Region: rs10788817

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.134
Position:
151882856
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
9.016
Reference Allele:
G
-log10(P):
-43.080
MAF:
0.399
Beta (Num):
0.027
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.107
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

Region: rs2762353

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.337
Position:
25794431
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-23.070
Reference Allele:
G
-log10(P):
-269.489
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.019
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/detoxification9[1], 10[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation11[1], 12[2]

Ratio Explanation:

The ratio of hexanoylglutamine to 3-hydroxylaurate reflects the balance between fatty acid conjugation for detoxification and beta-oxidation for energy, influenced by THEM4's acyl-CoA thioesterase activity.5[1], 9[2], 11[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

The THEM4 eQTL suggests its expression level affects the balance of fatty acid metabolism. Altered lipid metabolism, indicated by the ratio, can impact the composition and integrity of red blood cell membranes, leading to changes in hematological indices like MCHC, MCH, and MCV.5[1], 13[2], 14[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data