hexanoylglutamine to myristoleate (14:1n5)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.334
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-23.309
Reference Allele:
G
-log10(P):
-275.022
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.016
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Fatty Acid Metabolism.11[1], 12[2]

Ratio Explanation:

A higher ratio of hexanoylglutamine to myristoleate suggests altered fatty acid oxidation, potentially due to reduced ACADM activity impacting medium-chain fatty acid breakdown.3[1], 13[2], 14[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Defective ACADM function leads to an accumulation of upstream metabolites like hexanoylglutamine and alters fatty acid pools, which may impact red blood cell membrane composition and production, reflected in the associated hematological traits like MCHC, MCH, and Hb.13[1], 14[2]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data