hexanoylglutamine to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.339
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-24.413
Reference Allele:
G
-log10(P):
-301.427
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.022
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/oxidation6[1]

Ratio Explanation:

none

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

A missense variant in SLC17A4, an intestinal organic anion transporter, is associated with this ratio and phenotypes related to kidney function (creatinine, uric acid) and red blood cell indices.1[1], 2[2], 7[3], 8[4] SLC17A4's role in transporting urate and other anions likely influences these phenotypes.9[5]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data