hexanoylglutamine to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.321
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-23.331
Reference Allele:
G
-log10(P):
-275.541
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.003
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

Elevated hexanoylglutamine suggests incomplete fatty acid oxidation, a process in which ACADM is critical, while 10-nonadecenoate is a long-chain fatty acid.1[1], 5[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired ACADM function leads to the accumulation of upstream metabolites like hexanoylglutamine, a marker of inefficient fatty acid oxidation.11[1], 5[2] This metabolic disruption may contribute to phenotypes like altered red blood cell indices and serum creatinine, potentially through altered energy availability or lipotoxicity.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data