hexanoylglutamine to myristoylcarnitine (c14)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.329
Position:
25794431
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-22.673
Reference Allele:
G
-log10(P):
-260.381
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.011
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

Increased hexanoylglutamine may indicate increased fatty acid oxidation, while decreased myristoylcarnitine could result from impaired beta-oxidation, a process regulated by ACADM.9[1], 10[2], 7[3], 8[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM activity can impair fatty acid oxidation, potentially influencing hematological parameters like MCH and MCV, which are linked to HbA1c levels. This may connect to the observed associations with red blood cell indices.4[1], 5[2], 6[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data