hexanoylglutamine to eicosenoate (20:1)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.320
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-22.554
Reference Allele:
G
-log10(P):
-257.683
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.002
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism (long-chain fatty acid)8[1], 9[2]

Ratio Explanation:

Reduced ACADM function may impair beta-oxidation, leading to hexanoyl-carnitine accumulation which is then conjugated to glutamine, while eicosenoate metabolism is less directly affected.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired ACADM function leads to altered fatty acid oxidation, reflected by the ratio, potentially impacting energy availability and mitochondrial function, which could influence hematological indices.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data