hexanoylglutamine to tetradecanedioate (c14-dc)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of tetradecanedioate (c14-dc)
Metabolite Accession: GCST90199806
Name: tetradecanedioate (c14-dc)
Hmdb Id: HMDB0000872
Super Pathway: NA
Sub Pathway: NA
Inchikey: HQHCYKULIHKCEB

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.326
Position:
25794431
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-22.463
Reference Allele:
G
-log10(P):
-255.643
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation9[1], 10[2], 11[3]

Ratio Explanation:

This ratio reflects competing fatty acid fates; increased levels suggest reduced omega-oxidation (denominator) relative to glutamine conjugation (numerator), potentially due to altered CYP4B1 function.4[1], 12[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The CYP4 gene family (CYP4B1, CYP4A11) metabolizes fatty acids, producing signaling molecules like 20-HETE that regulate vascular tone.13[1], 14[2] Altered CYP4B1/A11 function, indicated by the ratio, likely perturbs this signaling, contributing to essential hypertension.5[3]

Phenotype Driver:

Gene-centric:CYP4B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data