hexanoylglutamine to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs2108622

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Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.133
Position:
15990431
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
8.358
Reference Allele:
C
-log10(P):
-37.292
MAF:
0.297
Beta (Num):
0.039
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.094
SE (Den):
0.016
No CNV overlap
rQTL cluster:
10
Reaction Distance:
NA
Closest Genes:
CYP4F2 CYP4F11 OR10H4 OR10H1 OR10H5

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.326
Position:
25809069
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-22.357
Reference Allele:
G
-log10(P):
-253.250
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.009
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, acyl glutamine metabolism. 6[1]

Denominator Metabolite Explanation:

Fatty acid ω-oxidation.

Ratio Explanation:

7[1], 8[2], 9[3] The ratio may reflect a shift in fatty acid metabolism, where decreased CYP4F2 function alters the balance between β-oxidation (numerator) and ω-oxidation (denominator).

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced CYP4F2 function could lead to increased hexadecanedioate, which is associated with elevated blood pressure and cardiovascular disease, potentially by impairing β-oxidation and shifting towards ω-oxidation, linking the gene to hypertension and atherosclerosis.

Phenotype Driver:

Gen10[1], 7[2], 11[3], 12[4], 9[5]e-centric:CYP4F2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data