hexanoylglutamine to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs1165195

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.479
Position:
25815080
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-23.739
Reference Allele:
G
-log10(P):
-285.166
MAF:
0.441
Beta (Num):
-0.317
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.162
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acyl glutamine)4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Steroidogenesis7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect a balance between fatty acid metabolism and steroid hormone synthesis, potentially influenced by shared transport or regulatory mechanisms involving SLC17A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters transport of urate and other anions, leading to changes in mean corpuscular hemoglobin, volume, and concentration, as well as hematocrit, hemoglobin, and serum creatinine levels, reflecting the gene's role in urate transport and its pleiotropic effects on hematological and renal function.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data