hexanoylglutamine to n-oleoyltaurine

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.275
Position:
46870761
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-14.378
Reference Allele:
C
-log10(P):
-106.264
MAF:
0.209
Beta (Num):
-0.036
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.3[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio may reflect FAAH activity, where higher ratios suggest increased hydrolysis of N-acyltaurines like n-oleoyltaurine, potentially impacting downstream signaling and energy balance.4[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, potentially from the missense variant, could decrease the breakdown of n-oleoyltaurine, altering the ratio. This change in lipid signaling may influence pathways related to energy metabolism and red blood cell characteristics, leading to the observed associations with MCHC, MCH, and Hb.1[1], 4[2]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data