hexanoylglutamine to 5-dodecenoylcarnitine (c12:1)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.326
Position:
25809069
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-22.413
Reference Allele:
G
-log10(P):
-254.509
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.008
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio may reflect a balance between fatty acid metabolism pathways, but a direct, well-defined relationship between hexanoylglutamine and 5-dodecenoylcarnitine is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The association of this ratio with phenotypes like MCHC, MCH, and Hb, along with uric acid, could be mediated by SLC17A4's role in urate and thyroid hormone transport, which can influence hematopoiesis and red blood cell indices.13[1], 14[2], 15[3], 16[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data