hexanoylglutamine to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs10788817

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.152
Position:
151882856
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
10.307
Reference Allele:
G
-log10(P):
-55.680
MAF:
0.399
Beta (Num):
0.027
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.125
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

Region: rs1177442

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.322
Position:
25809069
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-22.360
Reference Allele:
G
-log10(P):
-253.310
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.005
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Acyl-CoA metabolism

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

Impaired ACADM function may increase hexanoyl-CoA, the precursor of hexanoylglutamine, while affecting the metabolism of other fatty acids like tetradecadienoate, altering their relative abundance.4[1], 7[2], 8[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced ACADM activity due to genetic variants can impair fatty acid oxidation, leading to altered blood cell parameters (MCH, MCV, MCHC, Hb, Ht) and metabolic traits (creatinine, HbA1c, uric acid) due to downstream effects on energy metabolism and cellular function.4[1], 7[2], 9[3]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data