hexanoylglutamine to palmitate (16:0)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.323
Position:
25809069
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-22.214
Reference Allele:
G
-log10(P):
-250.053
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.006
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Amino acid conjugation.8[1], 9[2], 10[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis and beta-oxidation.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

The ratio may reflect a balance between fatty acid conjugation (hexanoylglutamine) and the availability of a primary saturated fatty acid (palmitate).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene likely influences kidney function and red blood cell parameters through its role as a transporter of urate and thyroid hormones.4[1], 15[2], 16[3], 17[4], 18[5], 19[6] Altered transport could affect serum urate and creatinine levels, and thyroid hormone status, which in turn can impact hematological indices.19[7], 20[8]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data