hexanoylglutamine to myristate (14:0)

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of myristate (14:0)
Metabolite Accession: GCST90200414
Name: myristate (14:0)
Hmdb Id: HMDB0000806
Super Pathway: NA
Sub Pathway: NA
Inchikey: TUNFSRHWOTWDNC

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.334
Position:
25809069
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-22.753
Reference Allele:
G
-log10(P):
-262.205
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.017
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.7[1], 8[2]

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism or transport, potentially influenced by SLC17A4's role as a solute carrier, although direct evidence is lacking.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The missense variant in SLC17A4, a transporter of urate and thyroid hormone, is associated with altered levels of uric acid and hematological phenotypes.2[1], 9[2] The ratio of hexanoylglutamine to myristate may reflect downstream metabolic perturbations, although a direct link is not established.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data