hexanoylglutamine to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.481
Position:
25809069
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-28.720
Reference Allele:
G
-log10(P):
-416.013
MAF:
0.441
Beta (Num):
-0.318
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.164
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glutamine)

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, Dicarboxylic acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio may reflect a shift in fatty acid metabolism, from detoxification via glutamine conjugation (numerator) to omega-oxidation (denominator), potentially influenced by transporter activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC17A4, an organic anion and thyroid hormone transporter, could alter systemic metabolic balance, reflected by the hexanoylglutamine to decadienedioic acid ratio and leading to changes in hematological parameters and metabolic markers like HbA1c and uric acid.1[1], 3[2]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data